Models of Inducing Hepatotoxicity in Rodents | Zoology

A toxic or repeated dose of a known hepatotoxin is administered to induce liver damage in experimental animals. The test substance is administered prior to or after the toxin treatment. If the hepatotoxicity is prevented or reduced, the test substance is effective. There are various models of inducing hepatotoxicity in rodents (rats and mice). Model # 1. Hepatitis in Long-Evans [...]